High‑intensity interval training can modulate the systemic infammation and HSP70 in the breast cancer: a randomized control trial / Ali Mohammad Alizadeh, Amin Isanejad, Sanambar Sadighi, Mahtab Mardani, Bita kalaghchi, Zuhair Mohammad Hassan

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Bibliografía: p.2592-2593

Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms
need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity
interval exercise training (HIIT) during hormone therapy would show improvements in low-grade infammation and HSP70
compared to the controls receiving standard care.
Methods Fifty two non-metastatic and hormone-responsive breast cancer patients were randomly assigned to high-intensity
interval exercise (HIIT) (n=26) and usual care (n=26) groups. The HIIT groups participated in a high-intensity interval
training protocol on a treadmill 3 days/week for 12 weeks. The training intensity was determined according to the predicted
maximal heart rate. Demographic characteristics and medical history were collected via an interviewer-administered questionnaire at the baseline visit. Body fat was estimated based on skinfold thickness measured with calipers on the participant’s
nonsurgery side at the triceps, suprailiac crest. VO2max was estimated by 1-Mile Rockport Walk Test. Blood samples were
collected 48 h before starting the exercise protocol and 48 h after the last exercise session. TNF-α, IL-6, IL-1β, IL-10, and
HSP70 levels in serum were measured using the enzyme-linked immunosorbent assay (ELISA) method according to the
manufacture’s instruction. Supernatant cytokine concentrations were determined by ELISA for IL-4 and IFN-γ. The data
were analyzed by ANCOVA test that the pretest values were considered as covariate at P≤0.05.
Results HIIT improved VO2max in the HIIT group compared to the usual care group (P=0.002). The serum levels of TNF-α
(P=0.001), IL-6 (P=0.007), and IL-10 (P=0.001) were lower in the HIIT group. The level of IL-4 (P=0.050) in the
stimulated peripheral blood mononuclear cells signifcantly increased in the HIIT group compared to the usual care group.
Furthermore, the serum level of the HSP70 was signifcantly higher in the HIIT group in comparison to the usual care group
(P=0.050). The TNF-α/IL-10 (P=0.050) and IL-6/IL-10 (P=0.042) ratios were lower in the HIIT group.
Conclusion The results of this study indicated that HIIT has positive impacts on the cardiorespiratory ftness and infammatory cytokines in the breast cancer patients undergoing hormone therapy.