High‑intensity interval training can modulate the systemic infammation and HSP70 in the breast cancer: a randomized control trial / (Record no. 13843)
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| fixed length control field | 03302nas a22002657a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220526170718.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
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| fixed length control field | 171219t2019 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0171-5216 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | Salus Infirmorum |
| 245 00 - TITLE STATEMENT | |
| Title | High‑intensity interval training can modulate the systemic infammation and HSP70 in the breast cancer: a randomized control trial / |
| Statement of responsibility, etc. | Ali Mohammad Alizadeh, Amin Isanejad, Sanambar Sadighi, Mahtab Mardani, Bita kalaghchi, Zuhair Mohammad Hassan<br/> |
| 500 ## - GENERAL NOTE | |
| General note | PDF en biblioteca |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliografía: p.2592-2593 |
| 520 8# - SUMMARY, ETC. | |
| Summary, etc. | Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms <br/>need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity <br/>interval exercise training (HIIT) during hormone therapy would show improvements in low-grade infammation and HSP70 <br/>compared to the controls receiving standard care.<br/>Methods Fifty two non-metastatic and hormone-responsive breast cancer patients were randomly assigned to high-intensity <br/>interval exercise (HIIT) (n=26) and usual care (n=26) groups. The HIIT groups participated in a high-intensity interval <br/>training protocol on a treadmill 3 days/week for 12 weeks. The training intensity was determined according to the predicted <br/>maximal heart rate. Demographic characteristics and medical history were collected via an interviewer-administered questionnaire at the baseline visit. Body fat was estimated based on skinfold thickness measured with calipers on the participant’s <br/>nonsurgery side at the triceps, suprailiac crest. VO2max was estimated by 1-Mile Rockport Walk Test. Blood samples were <br/>collected 48 h before starting the exercise protocol and 48 h after the last exercise session. TNF-α, IL-6, IL-1β, IL-10, and <br/>HSP70 levels in serum were measured using the enzyme-linked immunosorbent assay (ELISA) method according to the <br/>manufacture’s instruction. Supernatant cytokine concentrations were determined by ELISA for IL-4 and IFN-γ. The data <br/>were analyzed by ANCOVA test that the pretest values were considered as covariate at P≤0.05.<br/>Results HIIT improved VO2max in the HIIT group compared to the usual care group (P=0.002). The serum levels of TNF-α <br/>(P=0.001), IL-6 (P=0.007), and IL-10 (P=0.001) were lower in the HIIT group. The level of IL-4 (P=0.050) in the <br/>stimulated peripheral blood mononuclear cells signifcantly increased in the HIIT group compared to the usual care group. <br/>Furthermore, the serum level of the HSP70 was signifcantly higher in the HIIT group in comparison to the usual care group <br/>(P=0.050). The TNF-α/IL-10 (P=0.050) and IL-6/IL-10 (P=0.042) ratios were lower in the HIIT group.<br/>Conclusion The results of this study indicated that HIIT has positive impacts on the cardiorespiratory ftness and infammatory cytokines in the breast cancer patients undergoing hormone therapy. |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | breast cancer · |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HIIT |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cytokine |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-4 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IFN |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HSP70 |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | -- 2019, v. 145, n10, p. 2583-2593 |
| Title | Journal of Cancer Research and Clinical Oncology |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Artículo de revista |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type | Public note |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Universal Decimal Classification | Non-fiction | Revistas y artículos | Revistas y artículos | 26/05/2022 | PP | 5981 | 26/05/2022 | 26/05/2022 | Artículo de revista | Artículo de revista |