Importancia de polimorfismos genéticos de selectinas y factor tisular en la etiopatogenia de la enfermedad tromboembólica venenosa en pacientes jóvenes = (Record no. 12777)
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| fixed length control field | 03898nas a22003497a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210324175206.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171219t2007 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1130-5665 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | Salus Infirmorum |
| 245 00 - TITLE STATEMENT | |
| Title | Importancia de polimorfismos genéticos de selectinas y factor tisular en la etiopatogenia de la enfermedad tromboembólica venenosa en pacientes jóvenes = |
| Remainder of title | Role of genetic polymorphism in selectins and tissue factor in venous thromboembolism in young patients / |
| Statement of responsibility, etc. | Tàssies Penella M.D., Monteagudo Terres J., Reverter Calatayud J.C. |
| 500 ## - GENERAL NOTE | |
| General note | Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliografía: p. 321-322 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Estudiar la importancia de los polimorfismos de la P- selectina (Thr715Pro), del ligando de la P-selectina PSGL-1d (VNTR y M62l) y del factor tisular (-1208l/D en la etiopatogenia de la enfermedad tromboembólica venosa (ETV) en pacientes jóvenes<br/>Procedimientos: Se seleccionaron 82 pacientes con ETV y edad igaul o inferior a 50 años. Cuarenta y un pacientes con ETV idiopática(Grupo 1), (edad 34,4+-9.61 años; 51% mujeres) y 41 pacientes con ETV asociada a laos factores genéticos de trombofolia más prevalentes (factor V Leiden y mutación G20210A de la protrombina) (grupo 2) (edad 34.2+-11.7 años; 63% mujeres) 82 controles coluntarios sanos emparejados por edad y sexo. Los polimorfismos de P- selectina (Thr715Pro), PSGL-1 (VNTR y M 62l) y factor tisular (-1208l/) se determinaron por PCR.<br/>Resultados: No hubo diferencias en la distribución de genotipos de P- selectina Thr715Pro, PSGL-1 VNTR y factor tisular -1208l/D entre los controles y los grupos de pacientes. Para el polimorfismo de PSGL-1 M62l, la prevalencia de portadores heterocigotos (M/I) fue significativamente mayor en los pacientes del grupo 2 (25%) qu3 en los del grupo1 (15%) o en el grupo control (10%) (p>0.05)<br/>Conclusiones: Polimorfismo M62l de PSGL-1 pueden contribuir a la expresión trombótica en pacientes jóvenes protadores de factor V Leiden o mutación G20210A de la protrombina |
| 520 8# - SUMMARY, ETC. | |
| Summary, etc. | To study the importance of polymorphisms of P-selectin (Thr715Pro), of the P-selectin ligand PSGL-1d (VNTR and M62l) and of tissue factor (-1208l / D in the etiopathogenesis of venous thromboembolic disease (VTE) in young patients<br/>Procedures: 82 patients with VTE and igaul age or less than 50 years were selected. Forty-one patients with idiopathic VTE (Group 1), (age 34.4 + -9.61 years; 51% women) and 41 patients with VTE associated with the most prevalent thrombopholia genetic factors (factor V Leiden and prothrombin G20210A mutation ) (group 2) (age 34.2 + -11.7 years; 63% women) 82 healthy colony controls matched by age and sex. Polymorphisms of P-selectin (Thr715Pro), PSGL-1 (VNTR and M 62l) and tissue factor (-1208l /) were determined by PCR.<br/>Results: There were no differences in the distribution of genotypes of P-selectin Thr715Pro, PSGL-1 VNTR and tissue factor -1208l / D between controls and patient groups. For PSGL-1 M62l polymorphism, the prevalence of heterozygous carriers (M / I) was significantly higher in patients in group 2 (25%) qu3 in those in group1 (15%) or in the control group (10%) (p> 0.05)<br/>Conclusions: M62l polymorphism of PSGL-1 may contribute to thrombotic expression in young patients protonating factor V Leiden or prothrombin G20210A mutation |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | trombosis venosa |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | P-selectina |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | factor tisular |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PSGL-1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | micropartículas |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polimorfismos genéticos |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | venous trombosis |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | P-selectin |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | tissue factor |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PSGL-1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | microparticles |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genetic polymorphisms |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | -- 2007, v. 18, n. 4, p. 316-322 |
| Title | Mapfre Medicina |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Artículo de revista |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type | Public note |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Universal Decimal Classification | Non-fiction | Revistas y artículos | Revistas y artículos | 10/02/2020 | PP22 | 18(4):316-322 | 10/02/2020 | 10/02/2020 | Artículo de revista | Cajonera |