MARC details
| 000 -LEADER |
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| fixed length control field |
03748nas a22002897a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210420162528.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171219t2013 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Implicación de la molécula de adhesión ALCAM en el daño cerebral. Modelo de daño neuronal mediante la administración de MDMA/éxtasis en rata = |
| Remainder of title |
Implication of the adhesion molecule ALCAM in the experimental rat model of brain damage caused by MDMA/ecstasy / |
| Statement of responsibility, etc. |
Moreno Cubero E, O’Shea E, Rubio-Araiz A, Torres E, Urrutia A, Mayado A, Colado MI, Gutiérrez-López MD |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.106-108 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Caracterizar la expresión de ALCAM en vasos de corteza cerebral de ratas tratadas con MDMA. 2) Estudiar el efecto que sobre su expresión y sobre la neurotoxicidad producida por MDMA tiene ibuprofeno.<br/>Materiales y métodos: Se administró una dosis neurotóxica de MDMA a ratas Dark Agouti e buprofeno a diferentes<br/>tiempos. Se midió la temperatura de los animales durante los tratamientos y se estudió la expresión de ALCAM en los<br/>vasos de corteza. El daño cerebral se estudió midiendo los niveles de ácido 5-indolacético, serotonina y la densidad de<br/>su transportador.<br/>Resultados: MDMA produce un aumento de ALCAM a las 24 horas (p<0.01). El co-tratamiento con ibuprofeno<br/>lo disminuye (p<0.01) y atenúa el daño cerebral disminuyendo los efectos neurotóxicos de MDMA sobre los niveles de serotonina cortical (p<0.0001) y la densidad del transportador (p<0.0001). Ibuprofeno disminuye ligeramente la hipertermia producida por MDMA.<br/>Conclusiones: MDMA aumenta la expresión de ALCAM. Los datos sugieren la posibilidad de utilizar compuestos<br/>anti-inflamatorios como ibuprofeno que reducen este efecto sobre ALCAM y que disminuyen parcialmente el daño<br/>cerebral, si bien es necesario analizar la participación de la disminución de la temperatura en dicha protección. <br/> |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: 1) Characterization of ALCAM adhesion molecule expression in cortical vessels of MDMA-treated<br/>rats. 2) Study of the effect of the anti-inflammatory compound ibuprofen on ALCAM expression and on the neurotoxicity produced by MDMA.<br/>Material and methods: Male Dark Agouti rats were given a neurotoxic dose of MDMA. Ibuprofen was given before<br/>and at various times after MDMA. Rectal temperature was monitored during the treatment and ALCAM expression<br/>in vessels from cerebral cortex was determined at 24 h. In neurotoxicity studies, cortical 5-HT tissue levels and 5-HT<br/>transporter density were measured.<br/>Results: ALCAM expression was increased 24 h after MDMA treatment (p<0.01). Co-treatment with ibuprofen<br/>attenuated the increase in ALCAM levels (p<0.01) and partially prevented cerebral injury, reducing MDMA-induced 5-HT (p<0.0001) and 5-HT transporter (p<0.0001) loss. Ibuprofen produced a minor modification in the<br/>MDMA-induced hyperthermia.<br/>Conclusions: Our study demonstrates an effect of MDMA on ALCAM expression. Thus, anti-inflammatory compounds<br/>such as ibuprofen may result useful in brain protection by inhibiting the effects of ALCAM and reducing brain damage<br/>although the potential contribution of the attenuation of MDMA-induced hyperthermia must also be considered. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MDMA |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ALCAM |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurotoxicidad |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MDMA |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ALCAM |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurotoxicity |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2013, v. 24, n. 2, p. 101-108 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v24n2/docs/Articulo5.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v24n2/docs/Articulo5.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
