Modifiable life style factors and risk for incident endometriosis / Rachael Hemmert, Karen C. Schliep, Sydney Willis, Charles Matthew Peterson, Germaine Buck Louis, Kristina Allen-Brady, Sara E. Simonsen, Joseph B. Stanford, Jiyoung Byun, Ken R. Smith

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Bibliografía: p.24-25

Background: Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone- dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factors prior to endometriosis diagnosis.
Methods: Four hundred and seventy three women, ages 18- 44 years, underwent laparoscopy or laparotomy, regardless of clinical indication, at 14 clinic sites, 2007-2009. Women with prior surgically confirmed endometriosis were excluded. Lifestyle factors were assessed prior to surgery. Adjusted risk ratios (RR) of endometrio-sis by caffeine, alcohol, smoking (serum cotinine), and physical activity were esti-mated, adjusting for age, marital status, education, race/ethnicity, age at menarche, gravidity, BMI, study site, and other life style factors.
Results: There were no associations between women with endometriosis and alcohol consumption (RR 0.9, 95% CI 0.7, 1.3), caffeine consumption (RR 1.1, 95% CI 0.8, 1.5), or smoking (serum cotinine <10 vs ≥10 ng/mL; RR 1.0, 95% CI 0.7, 1.6). Similar null findings were found between endometriosis and weekly occurrences of physical ac-tivity and total walking, moderate, and vigorous activity; a modest trend was found between total daily sitting time and increased endometriosis risk.
Conclusions: This study, which is unique in its capture of life style exposures prior to incident endometriosis diagnosis, largely found no association between alcohol, caf-feine, smoking, and physical activity and risk of endometriosis.