MARC details
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03940nas a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210326145122.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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171219t2008 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Angiogénesis y vasculogénesis inducida por el trasplante intralesional de células madre mesenquimales adultas en un modelo experimental de daño medular traumático = |
| Remainder of title |
Angiogenesis and vasculogenesis induced by intralesional adult mesenchymal stem cell transplantation in an experimental spinal cord injury model / |
| Statement of responsibility, etc. |
Vaquero J, Bonilla C, Otero L, Aguayo C, Oya S, Zurita M |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 210-211 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivos: Estudiar si las células madre adultas mesenquimales, del estroma de la médula ósea (BMSC) contribuyen a la angiogénesis y vasculogénesis, tras su trasplante intralesional en la médula espinal traumatizada.<br/>Material y métodos: Se utilizó un modelo de lesión traumática medular estandarizada, en ratas Wistar y en cerdos adultos. A los 3 meses del traumatismo medular, en situación de paraplejia completa, se administraron intralesionalmente 3 x 106 BMSC marcadas mediante transfección génica con el gen LacZ (en la rata) y 30 x 106 BMSC marcadas con BrdU (en el cerdo). A los 3 meses del trasplante se estudió la zona del implante celular para detectar la presencia de vasos sanguíneos formados a expensas de las células trasplantadas.<br/>Resultados: Tanto en la rata Wistar como en el cerdo, se observaron numerosos vasos sanguíneos con células a nivel endotelial y en la pared del vaso que expresaban los marcadores propios de las células trasplantadas.<br/>Conclusiones: Las BMSC se pueden diferenciar in vivo hacia células endoteliales y hacia células musculares lisas, tras su trasplante intralesional en la médula espinal traumatizada, formando parte de nuevos vasos sanguíneos y contribuyendo a los fenómenos de angiogénesis y vasculogénesis necesarios para la regeneración del tejido nervioso lesionado. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objectives: To determine whether adult mesenchymal stem cells (bone marrow stromal cells, BMSCs) contribute to angiogenesis and vasculogenesis following their intralesional implantation in the damaged spinal cord.<br/>Material and methods: A standard spinal cord injury model was used in Wistar rats and adult pigs. Three months after spinal cord injury, under conditions of complete paraplegia, 3 x 106 BMSCs labeled via genic transfection with the LacZ gene (in rats), and 30 x 106 BMSCs labeled with BrdU (in pigs), were administered in the spinal lesion zone. Three months after implantation, the cell implant zone was studied to detect the presence of blood vessels formed at the expense of the transplanted cells.<br/>Results: In both the Wistar rats and pigs, numerous blood vessels were observed, with cells at endothelial level and in the vessel wall that expressed the markers inherent to the transplanted cells.<br/>Conclusions: BMSCs can differentiate under in vivo conditions towards endothelial cells and towards smooth muscle cells, following their intralesional transplantation in the damaged spinal cord – forming part of new blood vessels and contributing to the angiogenesis and vasculogenesis required for regeneration of the damaged nerve tissue. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre mesenquimales |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
terapia celular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
angiogénesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
vasculogénesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
traumatismo medular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mesenchymal stem cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell therapy |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
angiogenesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
vasculogenesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
spinal cord injury |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2008, v. 19, 4, p.206-211 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v19n4/pdf/02_02.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v19n4/pdf/02_02.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
