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03924nas a22003137a 4500 |
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OSt |
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20210326145143.0 |
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171219t2008 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Efecto neuroprotector de las células madre mesenquimales adultas en las fases iniciales de una lesión traumática de la médula espinal = |
| Remainder of title |
Neuroprotector effect of adult mesenchymal stem cells in the early phases after spinal cord injury / |
| Statement of responsibility, etc. |
Vaquero J, Bonilla C, Otero L, Aguayo C, Oya S, Zurita M |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 204-205 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivos: Estudiar el efecto de la administración precoz de células madre adultas mesenquimales sobre la apoptosis en las fases iniciales de un traumatismo medular experimental.<br/>Material y métodos: se sometieron 20 ratas Wistar adultas a una lesión traumática estandarizada por contusión, a nivel dorsal medio. Dos horas tras la lesión, 10 animales recibieron una inyección intralesional de 10μl de suero fisiológico y otras 10 recibieron 106 células madre mesenquimales adultas de médula ósea. Cinco animales de cada grupo se sacrificaron a las 8 horas y otros 5 animales a las 72 horas de la lesión. Se realizaron estudios histológicos e histomorfométricos con H&E y con marcador Mab F7-26 (apostain).<br/>Resultados: En los animales control, el número medio de células nerviosas expresando apostain fue de 138 ± 16, a las 8 horas de la lesión, y de 82 ± 13, a las 72 horas mientras que en el grupo tratado el número de células nerviosas marcadas con apostain fue de 76 ± 11, a las 8 horas, y de 57 ± 7, a las 72 horas tras la lesión con diferencias estadísticamente significativas entre ambos grupos (p< 0,05).<br/>Conclusión: La administración intralesional de células madre mesenquimales adultas ejerce un efecto neuroprotector<br/>en las fases precoces de un traumatismo medular grave disminuyendo el número de células nerviosas apoptóticas. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Aim: To study if the intralesional administration of adult mesenchymal stem cells modifies the number of apoptotic nervous cells in the early phases after severe spinal cord injury (SCI).<br/>Material and methods: Twenty adult Wistar rats were subjected to SCI at dorsal level. Two hours after the lesion,<br/>in 10 animals a volume of 10 μl of saline into the lesion were administered. Other 10 animalsreceived 106 bone marrow stromal cells obtained. Five animals of each group were sacrificed at the 8 hours after the lesion and the other 5 animals at the 72 hours. The spinal cord was processed in each animal for conventional histological studies and to identify cells in apoptosis using the marker Mab F7-26 (apostain). The number of cells in apoptosis with appearance of neurons or glial cells was quantified in each group, averaged and subjected to statistical comparisons.<br/>Results: In the control group the number of nervous cells expressing apostain was 138 ± 16, at the 8 hours and 82 ± 13 at the 72 hours after lesion. In the treated group the number of nervous cells expressing apostain was 76 ± 11, at the 8 hours, and 57 ± 7, at the 72 hours with statistically significant differences between the experimental groups.<br/>Conclusions: The intralesional administration of mesenchymal stem cells exercises an antiapoptotic effect in the precocious phases after severe SCI. <br/> |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre adultas |
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| Uncontrolled term |
apoptosis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
apostain |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
traumatismo medular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adult stem cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
apoptosis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
apostain |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
spinal cord injury |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2008, v. 19, 4, p.199-205 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v19n4/pdf/02_01.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v19n4/pdf/02_01.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
