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02847nas a22003137a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210420161320.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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171219t2012 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Administración de αB cristalina como nueva terapia para promover recuperación funcional en lesiones agudas de la médula espinal = |
| Remainder of title |
Administration of αB crystallin as a new therapy to promote functional recovery after acute spinal cord injury / |
| Statement of responsibility, etc. |
Klopstein A, Navarro X, López-Vales R |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.239 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Caracterizar la expresión y función de αB cristalina en la lesión medular.<br/>Material y método: En un modelo animal murino –mus musculus (ratón) de la cepa C57/Bl6– se realizó lesión medular mediante contusión, y los segmentos medulares fueron extraídos a los 1, 3, 7, 14, 21 y 28 días postlesión. Se valoraron los niveles de ARNm de αB cristalina. Asimismo, se administró αB cristalina recombinante humana tras la lesión medular y se valoró su efecto sobre la recuperación funcional.<br/>Resultados: Los niveles de expresión de αB cristalina no se incrementan hasta los 21 días post-lesión. La administración de dicha proteína promueve recuperación funcional tras la lesión medular.<br/>Conclusión: La administración de αB cristalina podría ser una nueva terapia para tratar las lesiones agudas de<br/>la médula espinal |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: Characterize the expression and role of αB crystallin in spinal cord injury Material and method: In a murine animal model (mus musculus (C57/Bl6 mouse) spinal cord injury was induced by contusion and the spinal cord segment corresponding to the injury site was extracted at day 1, 3, 7, 14, 21, 28 post-injury and αB crystallin mRNA levels were assessed. In addition, the effects of the administration of the human αB crystallin recombinant protein after spinal cord injury was evaluated.<br/>Results: αB crystallin mRNA levels did not increase until day 21 following spinal cord injury. Administration of αB crystallin resulted in increased functional recovery after lesion.<br/>Conclusion: Administration of αB crystallin could therefore be valuable for the treatment of acute spinal cord injury |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
αB cristalina |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
heat shock protein |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
inflamación |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lesión de médula espinal |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
αB crystallin |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
heat Shock Protein |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
inflammation |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
spinal Cord Injury |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2012, v. 23, n. 4, p. 235-239 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v23n4/docs/Articulo6.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v23n4/docs/Articulo6.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
