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022			_a2056-676X
040			_cSalus Infirmorum
245	0	0	_aTendinopathy / _cNeal L. Millar, Karin G. Silbernagel, Kristian Thorborg, Paul D. Kirwan, Leesa M. Galatz, Geoffrey D. Abrams, George A. C. Murrell, Iain B. McInnes and Scott A. Rodeo
500			_aEste artículo se encuentra disponible en su edición impresa.
504			_aBibliografía: p.17-21
520	8		_aTendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.
773			_g-- 2021, v. 7, n. 1, p. 1-21 _tNature Reviews Disease Primers
942			_2udc _cARTÍCULO
999			_c13060 _d13060