Assessing the risk to health care staff from long-term exposure to anticancer drugs – the case of monoclonal antibodies / 
Gabriele Halsen, Irene Krämer  
<br/><br/> PDF en biblioteca 
<br/><br/>Bibliografía: p.78-80 
<br/><br/> Today the occupational health and safety risk involved when handling most anticancer drugs is well recognized<br/>and, as a result of regulatory requirements, safety measures have been established. There is little knowledge<br/>about the occupational hazard posed by handling monoclonal antibodies assigned to ATC Class L01XC. The aim of<br/>our study was to evaluate the occupational risk of monoclonal antibodies. Using the information obtained in a systematic<br/>review of the literature, the potentially dangerous properties of the active drug substances were assessed using<br/>a specially devised algorithm. As a result, all monoclonal antibodies in question were categorized as substances<br/>with developmental toxicity. In addition, gemtuzumab ozogamicin was categorized as mutagenic. In view of the high<br/>molecular weights and the proteinogenic nature of monoclonal antibodies, the route of exposure for health care staff<br/>is limited to inhalation, unless there is an accident. Employers should implement the necessary administrative and<br/>engineering controls. Employees should adhere to the standards in order to avoid occupational exposure. The hazard<br/>assessment algorithm devised and the evaluation procedure may also be used for other drugs considered to be<br/>dangerous. 
<br/><br/><label>ISSN: </label>1477-092X 
<br/><br/><label>Subjects--Index Terms: </label>monoclonal antibodies ATC Class L01XC occupational exposure risk assessment occupational hazard