Estimating the Prevalence and Impact of Antidepressant-Induced Sexual Dysfunction in 2 European Countries: A Cross-Sectional Patient Survey / Valerie S. L. Williams ; David S. Baldwin, D.M. ; Susan L. Hogue, Pharm.D. ; Sheri E. Fehnel ; Kelly A. Hollis ; and Heather M. Edin

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Continuing resourceISSN: 0160-6689 In: Journal of Clinical Psychiatry -- 2006 v. 67, n 2, p.204-210Summary: Objective: Sexual dysfunction is a common side effect of antidepressant treatment, but recog-nition of the problem is variable. The aim of this study was to estimate the prevalence and impact of sexual dysfunction during antidepressant treat-ment in 2 European countries. Method: A cross-sectional survey of 502 adults in France and the United Kingdom. All participants were diagnosed with depression and taking a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), starting within the previous 3 months. Information was gathered about other medications and conditions known to impair sexual functioning, recent changes in sexual functioning, and the impact of any changes. The Medical Outcomes Study 12-Item Short-Form Health Survey and the Arizona Sexual Experience Scale were administered to measure health status and sexual functioning. Data were collected from June to July of 2002. Results: Applying a prevalence estimate algo-rithm, 26.6% of the French sample and 39.2% of the U.K. sample were classified as having antidepressant-induced sexual dysfunction; 34.2% of men and 32.5% of women were classified with antidepressant-induced sexual dysfunction. There was no clear pattern of antidepressant-induced sexual dysfunction related to specific antidepres-sants. Patients with antidepressant-induced sexual dysfunction reported that changes in sexual functioning negatively affected their self-esteem, mood, and relationships with sexual partners. 23.8% of the French sample and 25.2% of the U.K. sample reported that they perceived that their partner was dissatisfied with their sex life. Conclusion: The prevalence of antidepressant-induced sexual dysfunction in this study is similar to previous estimates reported in the literature. The impact of antidepressant-induced sexual dysfunction is substantial and negatively affects quality of life, self-esteem, mood, and relationships with sexual partners.

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Bibliografía: p.209-210

Objective: Sexual dysfunction is a common side effect of antidepressant treatment, but recog-nition of the problem is variable. The aim of this study was to estimate the prevalence and impact of sexual dysfunction during antidepressant treat-ment in 2 European countries.
Method: A cross-sectional survey of 502 adults in France and the United Kingdom. All participants were diagnosed with depression and taking a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), starting within the previous 3 months. Information was gathered about other medications and conditions known to impair sexual functioning, recent changes in sexual functioning, and the impact of any changes.
The Medical Outcomes Study 12-Item Short-Form Health Survey and the Arizona Sexual Experience Scale were administered to measure health status and sexual functioning. Data were collected from June to July of 2002.
Results: Applying a prevalence estimate algo-rithm, 26.6% of the French sample and 39.2% of the U.K. sample were classified as having antidepressant-induced sexual dysfunction; 34.2% of men and 32.5% of women were classified with antidepressant-induced sexual dysfunction. There
was no clear pattern of antidepressant-induced sexual dysfunction related to specific antidepres-sants. Patients with antidepressant-induced sexual
dysfunction reported that changes in sexual functioning negatively affected their self-esteem, mood, and relationships with sexual partners. 23.8% of the French sample and 25.2% of the U.K. sample reported that they perceived that their partner was dissatisfied with their sex life.
Conclusion: The prevalence of antidepressant-induced sexual dysfunction in this study is similar to previous estimates reported in the literature. The impact of antidepressant-induced sexual dysfunction is substantial and negatively affects quality of life, self-esteem, mood, and relationships with sexual partners.

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