Endometriosis : disease pathophysiology and the role of prostaglandins / Meng-Hsing Wu, Yutaka Shoji, Pei-Chin Chuang and Shaw-Jenq Tsai
Material type:
Continuing resourceISSN: 1462-3994
In:
Expert Reviews in Molecular Medicine -- 2007 v. 9, n.2, p.1-16Summary: Endometriosis is considered to be a polygenic disease with a complex, multifactorial aetiology that affects about 10% of women in the reproductive
age. Women with endometriosis have symptoms that include chronic pelvic pain, dysmenorrhoea and dyspareunia, significantly reducing their quality of
life. Endometriosis is also the primary cause of infertility in women, with the prevalence rate ranging from 20% to 50%. The high prevalence and severe
outcomes of this disease have made it a major public health concern in modern society. Currently, the mechanism(s) responsible for the initiation and
promotion of this disease remains obscure. In this review, we focus on the expression, regulation and action of prostaglandins in the cellular and
molecular mechanisms that contribute to the development and/or maintenance of endometriosis.
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Bibliografía: p.15-19
Endometriosis is considered to be a polygenic disease with a complex, multifactorial aetiology that affects about 10% of women in the reproductive
age. Women with endometriosis have symptoms that include chronic pelvic pain, dysmenorrhoea and dyspareunia, significantly reducing their quality of
life. Endometriosis is also the primary cause of infertility in women, with the prevalence rate ranging from 20% to 50%. The high prevalence and severe
outcomes of this disease have made it a major public health concern in modern society. Currently, the mechanism(s) responsible for the initiation and
promotion of this disease remains obscure. In this review, we focus on the expression, regulation and action of prostaglandins in the cellular and
molecular mechanisms that contribute to the development and/or maintenance of endometriosis.
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