Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial / (Record no. 15317)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02783nas a22002777a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250130134948.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171219t2021 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1028-415X |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | Salus Infirmorum |
| 245 0# - TITLE STATEMENT | |
| Title | Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial / |
| Statement of responsibility, etc. | Neda Haghighat, Shirin Rajabi and Majid Mohammadshahi<br/><br/> |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliografía: p 498-499 |
| 520 8# - SUMMARY, ETC. | |
| Summary, etc. | Background: The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on the depression and anxiety symptoms and serum brain-derived neurotrophic factor (BDNF) level.<br/>Methods: Seventy-five HD patients were randomly assigned to receive the synbiotic (15 g of prebiotics, 5 g of probiotic containing Lactobacillus acidophilus T16, Bifidobacterium bifidum BIA-6, Bifidobacterium lactis BIA-7, and Bifidobacterium longum BIA-8 (2.7 × 107 CFU/g each)) or probiotics (5 g probiotics as in synbiotic group with 15 g of maltodextrin as placebo) or placebo (20 g of maltodextrin) for 12 weeks. Serum BDNF was measured by ELISA kit. Hospital Anxiety and Depression Scale (HADS) was used to assess symptoms of depression (HADS-DEP) and anxiety (HADS-ANX).<br/>Results: From baseline to 12 weeks, synbiotic supplementation resulted in a significant decrease in HADS-DEP score in a subgroup of patients with depressive symptom (HADS-DEP ≥ 8) compared to the placebo and probiotic supplementation (p = .001, p = .002, respectively) and in all patients<br/>compared to the placebo (p = .004). There was no significant difference among the groups in terms of HADS-ANX scores. However, the HADS-ANX scores decreased significantly in the synbiotic group compared to the baseline in all patients (p = .047) and also patients with depressive symptom (p = .03). In addition, in a subgroup of HD patients with depressive symptom, the serum BDNF increased significantly in the synbiotic group when compared to the placebo (p < .001) and probiotic group (p = .011).<br/>Conclusion: Overall, 12 weeks of synbiotic supplementation resulted in greater improvement in depression symptoms and serum BDNF level compared to the probiotic supplementation in HD patients especially in the subgroup of patients with depression symptoms. |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brain-derived neurotrophic factor |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BDNF |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | hemodialysis |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | depression |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | probiotic |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | synbiotic |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | anxiety |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | gastrointestinal microbiome |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | -- 2021, v. 24, n 6, p.490-499 |
| Title | Nutritional Neuroscience |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Artículo de revista |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Universal Decimal Classification | Non-fiction | Revistas y artículos | Revistas y artículos | 30/01/2025 | PP | 6277 | 30/01/2025 | 30/01/2025 | Artículo de revista |