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03440nas a22003257a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210322190012.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
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171219t2005 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1130-5665 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Cotrasplante de células de Schwann y células madre mesenquimales en la paraplejia traumática experimental = |
| Remainder of title |
Co-transplantation of Schwann cells and mesenchymal stem cells in experimental traumatic paraplegia / |
| Statement of responsibility, etc. |
Zurita M., Vaquero J., Oya S., Aguayo C. |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 288 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Teniendo en cuenta observaciones previas acerca de la utilidad de factores neurotróficos liberados por células de Schwann para incrementar los fenómenos regenerativos en la médula espinal traumatizada, en el presente estudio hemos trasplantado una mezcla de células de Schwann (5 x 105) y células madre mesenquimales (CMM) adultas, obtenidas del estroma de médula ósea (3 x 106) en la cavidad centromedular postraumática de ratas Wistar adultas, previamente parapléjicas por una lesión traumática severa de la médula espinal. La recuperación motora fue evaluada de acuerdo a la escala de BBB en los seis meses siguientes a la intervención y se comparó con la recuperación obtenida tras la administración de CMM (3 x 106) sin células de Schwann. Los resultados confirman que la administración intralesional de CMM en la cavidad centromedular postraumática va seguida de una importante y progresiva recuperación motora en animales con una paraplejia crónicamente establecida. Sin embargo, el cotrasplante con células de Schwann, al menos con los parámetros experimentales utilizados en el presente estudio, no obtuvo diferencias estadísticamente significativas con respecto a la administración de CMM sin células de Schwann. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Keeping in mind previous observations about the utility of neurotrophic factors released by Schwann cells and increasing regeneration in the injured spinal cord, in the present study we grafted a mixture of Schwann cells (5 x 105) and bone marrow stromal cells (CMM), (3 x 106) into the postraumatic centromedullary cavity of adult Wistar rats, previously paraplegic due to severe spinal cord injury. The recovery of motor function was evaluated according to the scale of BBB in the six following months, and it was compared with the recovery obtained after the administration of CMM (3 x 106) without Schwann cells. Our results confirm that intralesional administration of CMM in the postraumatic centromedullary cavity achieves important and progressive functional recovery in animals suffering a chronically established paraplegia. However, the cograft with Schwann cells, at least with the experimental parameters used in the present study, did n¿t obtain statistically significant differences with regard to the administration of CMM without Schwann cells. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
paraplegia |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre adultas |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre mesenquimales |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células de Schwann |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
transplantes neurales |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
paraplegia |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adult stem cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mesenchymal stem cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Schwann cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neural transplantation |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2005, v. 16, 4, p. 284-288 |
| Title |
Mapfre Medicina |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
