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04176nas a22003737a 4500 |
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OSt |
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20210323145826.0 |
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ta |
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171219t2005 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1130-5665 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
LGF («LIVER GROWTH FACTOR») como factor de proliferación, migración y diferenciación de las células madre neurales y su posible utilidad en enfermedad de Parkinson = |
| Remainder of title |
LGF («LIVER GROWTH FACTOR») as a factor involved in the proliferation, migration and differentiation of neural stem cells: Potential use in Parkinson´s disease / |
| Statement of responsibility, etc. |
Bazán E., Herranz A.S., Alonso R., Díaz-Gil J.J., Lobo Mª. V.T., Paíno C.L., Asensio Mª.J. |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 245-247 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
El factor de crecimiento de hígado, LGF, es un factor de proliferación y regeneración en distintos tipos celulares, y estudios preliminares fundamentan su posible uso en terapias neuroregenerativas. El objetivo del trabajo ha sido comprobar si el LGF estimula la proliferación celular y la neurogénesis en el modelo experimental de enfermedad de Parkinson (EP) de lesión con 6-OHDA. La administración intraventricular de LGF incrementó la incorporación de bromodeoxiuridina (BrdU) y la expresión de los marcadores de células madre neurales (CMN) nestina y proteina ácida de la glía, observándose células doblemente marcadas para BrdU y nestina en la zona subventricular y el parénquima estriatal. Sin embargo, no se encontraron células BrdU-positivas/ b tubulina III-positivas, sugiriendo que el LGF no es un factor neurogénico para las CMN de la zona subventricular. La infusión intraestriatal de LGF no afectó a la proliferación celular, pero aumentó significativamente el número de terminales tirosina hidroxilasapositivos en el estriado denervado y mejoró la conducta rotacional provocada por apomorfina. Las conclusiones son: 1) la infusión intraventricular de LGF estimula la proliferación y migración de las CMN; y 2) la infusión intraestriatal de LGF estimula la regeneración de los terminales dopaminérgicos dañados, lo que podría explicar la discreta mejoría conductual observada en estos animales |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Liver growth factor (LGF) promotes the proliferation and regeneration of different cell types, and preliminary studies indicate that LGF might be useful for neuroregenerative therapies. The aim of this work was to study the cell proliferative and neurogenic effects of LGF in a 6-OHDA Parkinson¿s disease (PD) experimental model. Intraventricular infusion of LGF increased bromodeoxyuridine (BrdU) incorporation in the subventricular zone and striatum. In addition, the striatum ipsilateral to LGF infusion showed a higher expression of neural stem cell (NSC) markers nestin and glial fibrillary acidic protein, and the presence of cells double-labeled for BrdU and nestin. However, no BrdU-positive/ B tubulin III-positive cells were observed, suggesting that LGF is not a neurogenic factor. Intrastriatal LGF infusion significantly increased the number of tyrosine hydroxylase-positive fibers in the striatum of dopamine-denervated rats. Moreover, apomorphine-induced behavioral rotations improved in these animals. We conclude that: 1) Intraventricular LGF infusion stimulates neural stem cell proliferation and migration; and 2) Intraestriatal LGF infusion stimulates the regeneration of dopaminergic terminals in the striatum, which might explain the partial behavioral recovery observed in these animals |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurogénesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre neurales |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neuroregeneración |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
factores tróficos |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
dopamina |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
enfermedad de Parkinson |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
liver growth factor |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurogénesis |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neural stem cells |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neuroregeneration |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
trophic factors |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
dopamine |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Parkinson´s disease |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
liver growth factor |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2005, v. 16, 4, p. 237-247 |
| Title |
Mapfre Medicina |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
