Influencia de los polimorfismos en genes de metabolización de carcinógenos y riesgo de cáncer de pulmón = (Record no. 12775)
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| fixed length control field | 03989nas a22003257a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210324175244.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171219t2007 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1130-5665 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | Salus Infirmorum |
| 245 00 - TITLE STATEMENT | |
| Title | Influencia de los polimorfismos en genes de metabolización de carcinógenos y riesgo de cáncer de pulmón = |
| Remainder of title | Metabolic gene polymorphisms and lung cancer risk / |
| Statement of responsibility, etc. | Domínguez-García A., Fernández-Rubio A., López-Cima M.F., González-Arriaga P., García-Castro L., Pascual T., G. Marrón M, Puente X.S., Tardón A. |
| 500 ## - GENERAL NOTE | |
| General note | Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliografía: p. 303-304 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Objetivo:<br/>Comprobar que plomorfismos implicasdos en genes del metabolismo de carcinógenos pueden contribuir a las sisceptibilidad individual a desarrollar cáncer de pulmón. Hemos estudiado la relación entre dos plomorfismos en estos genes (CYP1A1 Mspl y GSTP lle105Val y el riesgo de desarrollar cáncer de pulmón.<br/>Diseño: estudio caso control de base hospitalaria que incluye 406 casos incidentes de cáncer de pulmón y 436 controles apareados por edad, género y área geográfica. Los genotipors fueron determinados por PCR-RFLP y los resultados fueron analizados usando un montón de regresión logística<br/>Resultados: esncontramos asociaciñon entre el polimorfismo CYP1A1Mspl y el riesgo de desarrollar cáncer de pulmón mientras que no entontramos acosicación al estuidiar el polimorfismo GSTP1 lle105Val. El valor de la OR ayustada obtenida en el caso del CYP1A1Mspl es de 1.47; 955 Cl= 0.35-6.14, lo cual indica que aumneta el riesgo a desarrollar cáncer de pulmón aunque nuestros datos no son estadísticamente significativos.<br/>Por otra partem parece qu el genotipo hetecigotico para el polimorfismo GSTP1 lle105Val tiene una papel protector frente al desarrollo del cáncer de pulmón en mujeres (OR ajustada= 0.22; Cl= 0.09-0.56)<br/>Conclusión: nestros resultados apoyan la hipótesis de que polimorfísmos en genes implicados en el metabolismo de carcinogénos y sus combinaciones pueden influir en la etiología del cáncer de pulmón. |
| 520 8# - SUMMARY, ETC. | |
| Summary, etc. | Objective:<br/>Check that plomorphisms involved in carcinogen metabolism genes can contribute to individual sisceptibility to develop lung cancer. We have studied the relationship between two plomorphisms in these genes (CYP1A1 Mspl and GSTP lle105Val and the risk of developing lung cancer.<br/>Design: hospital-based control case study that includes 406 incident cases of lung cancer and 436 controls matched by age, gender and geographic area. The genotipors were determined by PCR-RFLP and the results were analyzed using a lot of logistic regression<br/>Results: We found an association between the CYP1A1Mspl polymorphism and the risk of developing lung cancer while we did not find a harassment when studying the GSTP1 polymorphism lle105Val. The value of the assisted OR obtained in the case of CYP1A1Mspl is 1.47; 955 Cl = 0.35-6.14, which indicates that it increases the risk of developing lung cancer although our data are not statistically significant.<br/>On the other hand, it seems that the hetecigotic genotype for GSTP1 polymorphism lle105Val has a protective role against the development of lung cancer in women (adjusted OR = 0.22; Cl = 0.09-0.56)<br/>Conclusion: Our results support the hypothesis that polymorphisms in genes involved in the metabolism of carcinogens and their combinations may influence the etiology of lung cancer. |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cáncer de pulmón |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polimorfismo |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | citocromo P450 1A1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glutatión transferasa P1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genes de metabolización |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | lung cancer |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polymorphism |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cytochrome P4501A1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glutation transferase P1 |
| 653 14 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metabolic gene |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | -- 2007, v. 18, n. 4, p. 292-304 |
| Title | Mapfre Medicina |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Artículo de revista |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type | Public note |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Universal Decimal Classification | Non-fiction | Revistas y artículos | Revistas y artículos | 10/02/2020 | PP22 | 18(4):292-304 | 10/02/2020 | 10/02/2020 | Artículo de revista | Cajonera |