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04741nas a22003377a 4500 |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210325134853.0 |
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171219t2009 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1575-4146 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Modelo experimental de infarto agudo de miocardio y reperfusión con tórax cerrado en cerdos: monitorización cardiaca = |
| Remainder of title |
Experimental model of acute myocardial infarction and reperfusion in pigs with closed thorax: cardiac monitoring / |
| Statement of responsibility, etc. |
Álvarez García M., Fariñas Carrizo E., Hurtado Álvarez B., Regueiro Purriños M. |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.42 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Introducción: El desarrollo de la medicina regenerativa cardiovascular condiciona la necesidad de disponer de modelos experimentales animales similares al corazón humano con respecto a tamaño, anatomía y fisiología. Nuestro objetivo fue analizar la viabilidad y reproducibilidad de un modelo porcino de infarto y reperfusión a tórax cerrado mediante técnicas endovasculares, que soslayen los inconvenientes de las técnicas quirúrgicas más agresivas. Material y métodos: En 15 cerdos domésticos (Large White), anestesiados y pretratados con amiodarona, se realizó un procedimiento endovascular de oclusión coronaria guiada por fluoroscopia en la arteria descendente anterior media mediante inflado de balón de angioplastia coronaria. Tras 75 minutos de oclusión coronaria, demostrada angiográfica y electrocardiográficamente, se retiró el sistema confirmándose la reperfusión. Resultados: El procedimiento se completó con éxito en todos los casos. La complicación más frecuente fue la fibrilación ventricular (FV) (87%): 7 animales fibrilaron una vez y 6 en más de una ocasión. Se documentaron 20 episodios de FV y todos respondieron a la desfibrilación. Mediante monitorización continua en el momento de la oclusión coronaria se detectó un descenso significativo, de la FC (84 ± 19 vs. 75 ± 17, p= 0.006) y de la PAM (64 ± 6 vs. 53 ± 12 mmHg., p< 0.0001); en el momento de la reperfusión, no se objetivó ninguna variación significativa. Los valores de capnometría y pulsioxímetro sufrieron variaciones significativas durante el procedimiento. Conclusiones: Nuestro modelo porcino de infarto y reperfusión con tórax cerrado es factible y reproducible. La complicación más frecuente es la FV. Tras la oclusión coronaria se aprecian caídas significativas de la FC y PAM. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Background: The development of cardiovascular regenerative medicine requires the availability of effective experimental animal models comparable to the human situation. Our objective was to assess the viability and reproducibility of an endovascular porcine model of myocardial infarction and reperfusion that obviates the limitations of more invasive surgical models. Material and methods: In 15 domestic pigs (Large White), anesthetized and pre-treated with amiodarone, endovascular and fluoroscopy-guided coronary procedures were performed; mid-left anterior descending artery was occluded with a coronary angioplasty balloon. After 75 minutes of occlusion, confirmed by angiography and electrocardiography, the balloon catheter system was withdrawn and existence of reperfusion flow was verified. After 1 and 2 weeks follow-up periods, hearts were explanted and the size of myocardial infarction was quantified. Results: Global survival rate was 67% as 5 animal died prematurely: 3 of them showed signs of heart failure, 1 had failed reperfusion (final TIMI flow grade 1) and 1 died after a stress event. The most common adverse event was ventricular fibrillation, which appeared in 87% of the animals; defibrillation was effective in all the cases. The size of myocardial infarct was similar among animals followed by 1 and 2 weeks (27 ± 4% vs. 28 ± 2% of left ventricular surface area, p= 0.6), but was significantly greater in the cases that prematurely died (39 ± 2%, p< 0.0001). Conclusions: The endovascular porcine model of myocardial infarction and reperfusion we have developed is feasible and shows reproducible results. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
modelo experimental |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
infarto |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
oclusión coronaria |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
reperfusión miocárdica |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
monitorización |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
myocardial infarction |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
reperfusion |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cardiac catheterization |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
animal models |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
swine |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2009, v. 16, n. 46, p. 39-42 |
| Title |
Enfermería en Cardiología |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://www.enfermeriaencardiologia.com/wp-content/uploads/4607.pdf">https://www.enfermeriaencardiologia.com/wp-content/uploads/4607.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
