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03668nas a22003137a 4500 |
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OSt |
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20210326131739.0 |
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171219t2008 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Marcadores moleculares de inflamación en la depresión post-ictus = |
| Remainder of title |
Molecular markers of inflammation in post-stroke depression / |
| Statement of responsibility, etc. |
Jiménez I, Sobrino T, Brea D, Cristobo I, Rodríguez-Yáñez M, Blanco M, Pouso M, Sabucedo M, Leira R, Castillo J |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 118-119 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: evaluar la respuesta inflamatoria sistémica durante la fase aguda del ictus isquémico y establecer la relación entre los niveles de Factor Neurotrófico derivado del Cerebro (BDNF), IL-6, ICAM-1, el pronóstico del ictus y la incidencia de depresión.<br/>Material y métodos: Estudio prospectivo sobre 104 pacientes con primer episodio de ictus isquémico. Se recogieron antecedentes familiares de depresión y enfermedad psiquiátrica y datos familiares. Se realizó un TAC o RNM. La depresión se evaluó en el momento del alta y al mes, siguiendo el DSM IV. De muestras de sangre se obtuvieron los niveles de IL-6 e ICAM-1, BDNF.<br/>Resultados: De 104 pacientes, 54 presentaron depresión al alta y 25 depresión mayor. La depresión se relacionó con: sexo femenino, viudedad, vivir con los hijos y edad. No se halló relación con la gravedad del ictus, el grado de afectación funcional, la localización o el volumen del infarto. Tampoco entre los marcadores estudiados y la depresión tras el ictus.<br/>Conclusión: Los pacientes que desarrollan depresión tras el ictus, presentan peor pronóstico funcional, independiente del grado de afectación neurológica y de la localización de la lesión. No establecimos asociación entre la depresión y los marcadores de inflamación. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Introduction: Depresión is frequent after stroke, finding an association with inflammation. Our aim is to evaluate the relationship between inflammation in acute phase of stroke and depression.<br/>Patients and methods: We included 134 patients with first ischemic stroke, excluding previous history of depression, and aphasia. Stroke severity was evaluated by NIHSS and functional outcome by modified Rankin Scale (mRS) and Barthel Index (BI). Depression was evaluated at discharge and at 1 month by DSM-IV criteria and Yesavage Scale, Serum levels of inflammatory molecules (IL-6, ICAM 1 and high-sensitive-CRP) and BDNF were determined at discharge.<br/>Results: 40,3% of patients showed depression at discharge and 48.1% at one month. Patients with depression at one month showed poor outcome (BI 70 [90,100] vs 100 [95,100]; p=0,001; mRS 2 [1,3] vs 1 [0,2]; p=0,03). Depression at discharge was independently associated with live with offspring (OR: 7,62; CI95% [1,35, 43,09]; p=0,022), and at one month with female sex (OR:5,47; CI95% [1,45,20,67]; p=0,012) and depression at discharge (OR: 9,36; CI95% [2,46,35,59]; p=0,002). We found no relationship between the molecular markers and the depression after stroke.<br/>Conclusion: No relationship was found between inflammation in acute phase and post-troke depression. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Ictus |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
depresión |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
BDNF |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
IL-6 |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
depression |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
stroke |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
BDNF |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
IL-6 |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2008, v. 19, 2, p. 113-119 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v19n2/pdf/02_07.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v19n2/pdf/02_07.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
