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03210nas a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210326132135.0 |
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ta |
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171219t2008 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Efecto de la LDL modificada en la expresión de adipofilina en macrófagos y células musculares lisas de la pared vascular. Implicaciones para el desarrollo de arteriosclerosis = |
| Remainder of title |
Effect of modified LDL in the expression of adipocyte differentiation-related protein in macrophages and vascular smooth muscle cells. Implications for atherosclerosis progression / |
| Statement of responsibility, etc. |
Llorente-Cortés V, Royo T, Juan-Babot O, Badimon L |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 158-159 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Analizar si la unión e interiorización de la LDL modificada por agregación (LDLag) puede inducir la expresión de la proteina adipofilina (ADRP), un marcador de acumulación lipídica, en las células musculares lisas de la pared vascular (CMLV) y macrófagos humanos.<br/>Resultados: La LDLag induce la sobreexpresión de ADRP tanto a nivel de ARNm (PCR tiempo real) como a nivel de proteina («western blot») en CMLV (ARNm: 3.06-veces; proteina: 8.58-veces) y también en macrófagos (ARNm: 3.5-veces; proteina: 3.71-veces). Los estudios immunohistoquímicos evidenciaron una alta colocalización entre ADRP y CMLV y también entre ADRP y macrófagos en placas ateroscleróticas avanzadas ricas en lípido.<br/>Conclusiones: La captación de LDLag mediante el receptor lipoproteíco LRP1 juega un papel primordial en la formación de células espumosas a partir de macrófagos y de CMLV y, por tanto, en la progresión de la lesión aterosclerótica. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Aims: The objectives of this work were to analyze whether aggregated LDL (agLDL) uptake modulates ADRP expression levels in human vascular smooth muscle cells (VSMC) and macrophages (HMDM).<br/>Methods and Results: AgLDL strongly upregulated ADRP mRNA (Real-time PCR) and protein expression (western blot) in human VSMC (mRNA: by 3.06-fold; protein: 8.58-fold) and HMDM (mRNA: by 3.5-fold;<br/>protein: by 3.71-fold).. Immunohystochemical studies evidence a high colocolocalization between ADRP/macrophages and ADRP/VSMC in advanced lipid-enriched atherosclerotic plaques.<br/>Conclusions:These results demonstrate that agLDL-LRP1 engagement induces ADRP overexpression in both HMDM and human VSMC. ADRP is highly expressed in advanced lipid-enriched human atherosclerotic plaques. Therefore, LRP1-mediated agLDL uptake might play a pivotal role on vascular foam cell formation and atherosclerotic plaque progression. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adipofilina |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
LDL agregada |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
LRP1 |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células musculares lisas de pared vascular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
macrófagos |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
aggregated LDL |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
LRP1 |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adipophilin |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
human VSMC |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
macrophages |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2008, v. 19, 3, p. 152-159 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v19n3/pdf/02_03.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v19n3/pdf/02_03.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
