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04115nas a22003137a 4500 |
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OSt |
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20210406170526.0 |
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171219t2009 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Recuperación de la habilidad motora mediante trasplantes neurales en ratas adultas con lesión de la corteza frontal = |
| Remainder of title |
Motor skill recovery through neural transplants in adult rats with frontal cortex damage / |
| Statement of responsibility, etc. |
Heredia M, Riolobos A S, de la Fuente A, Criado J M, Yajeya J |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 142-143 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Investigar los mecanismos involucrados en la recuperación funcional de alteraciones motoras producidas por la lesión de la corteza frontal mediante trasplantes neurales embrionarios, en ratas adultas.<br/>Material y metodología: Utilizamos ratas machos, de raza Wistar, empleando pruebas conductuales, métodos electrofisiológicos y técnicas inmunohistoquímicas e histológicas. Los animales se condicionaron en un test motor específico de habilidad motora fina y se determinó su mano preferente. Se realizó una lesión en la corteza frontal contralateral a la mano preferente y se evaluó la efectividad de la lesión mediante el test de conducta. En un grupo de animales lesionados se trasplantó tejido cortical embrionario en la cavidad producida por la lesión; en un segundo grupo, se utilizó tejido fetal amigdalino como tejido donante; y en un tercer grupo, se trasplantó nervio ciático de rata adulta. Los tres grupos se compararon con un grupo de animales control.<br/>Resultados: A los tres meses post-trasplante, los animales con trasplantes de tejido fetal amigdalino y con trasplantes de tejido cortical mejoraron el déficit motor producido por la lesión. Los animales con trasplantes de nervio ciático no presentaron ninguna mejoría.<br/>Conclusión: Los trasplantes de tejido amigdalino inducen una mejoría similar a la obtenida con los trasplantes de tejido cortical. El origen ontogenético, en parte común, del tejido amigdalino y el tejido cortical podría estar implicado en los mecanismos subyacentes a la recuperación funcional. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objetive: To investigate the mechanisms by which neural transplants contribute to functional recovery of the motor disorders produced by frontal cortex damage in adult rats.<br/>Material and methods: Male Wistar rats were used, with the application of behavioral tests, electrophysiological methods and immunohistochemical and histological techniques. The animals were conditioned using a specific fine motor skill test, with determination of the dominant paw. Damage was produced in the frontal cortex contralateral to the dominant paw, with evaluation of the effectiveness of the lesion based on the behavioral test. In one group of damaged animals embryonic cortical tissue was implanted in the cavity left by the lesion. In a second group fetal amygdaline tissue was used as donor material, while in a third group adult rat sciatic nerve was implanted. The three groups were compared with a control group.<br/>Results: Three months after grafting, the rats with fetal amygdaline tissue and with transplanted cortical material improved of the motor defect induced by the lesion. The rats with grafted sciatic nerve showed no improvement.<br/>Conclusion: Amygdaline tissue grafts induce improvement similar to that recorded with cortical tissue transplants. The partially shared ontogenetic origin of amygdaline and cortical tissue could be implicated in the functional recovery mechanisms. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
corteza motora |
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| Uncontrolled term |
trasplantes neurales |
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| Uncontrolled term |
test de habilidad motora |
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| Uncontrolled term |
rata adulta |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
motor cortex |
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| Uncontrolled term |
neural transplants |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
motor skill test |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adult rat |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2009, v. 20, 3, p.137-143 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v20n3/pdf/02_02.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v20n3/pdf/02_02.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
