MARC details
| 000 -LEADER |
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| fixed length control field |
03513nas a22002897a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20210406170902.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171219t2009 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Estudio de la utilidad del gel de fibrina como soporte celular en el trasplante intracerebral de células madre mesenquimales = |
| Remainder of title |
Study of the usefulness of fibrin gel as a biological scaffold for intracerebral transplantation of mesenchymal stem cells / |
| Statement of responsibility, etc. |
Bonilla C, Otero L, Aguayo C, Rodríguez A, Zurita M, Vaquero J |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 248 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Analizar el efecto de células madre del estroma de médula ósea en los traumatismos cerebrales.<br/>Material y Método: Se causó trauma cerebral por contusión, en 20 ratas Wistar adultas. A los 2 meses se transplantó CM adultas (3x106), como suspensión en suero fisiológico (volumen total de 30 µL). En 10 animales se inyectó directamente sobre la zona de lesión traumática cerebral y en otros 10 animales sobre una malla de gel de fibrina insertada en la lesión. La evolución funcional de los animales se estudió mediante los tests de mNSS y Rota-rod.<br/>Resultados: Todos los animales mostraron déficit funcional tras la lesión traumática, con mejoría significativa tras el trasplante intracerebral de CM, sin diferencias estadísticamente significativas entre ambos grupos experimentales.<br/>Conclusión: La inserción de una malla de fibrina en una lesión cerebral traumática, como soporte para la administración intralesional de CM no parece ser una técnica útil para optimizar los resultados funcionales obtenidos con este tipo de terapia celular. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objetive: To analyze the effect of intracerebral transplantation of adult stem cells obtained from bone marrow stroma in<br/>an experimental model of traumatic brain injury.<br/>Material and Method: We performed a traumatic brain contusion in 20 adult Wistar rats. At 2 months of injury, 3x106<br/>bone marrow stromal cells as saline suspension of CM, with a total volume of 30 μL, was injected in the area of traumatic brain injury. In 10 animals the injection was made directly over the traumatic brain injury and in other 10 animals the injection was made on the mesh of fibrin gel. The functional evolution of animals was studied from injury to two months after transplantation using the mNSS test and the Rota-rod test.<br/>Results: All animals showed a clear and significant functional deficits after traumatic injury, and experienced significant<br/>improvement after intracerebral transplantation of bone marrow stromal cells, with no statistically significant differences<br/>between experimental groups.<br/>Conclusion: The insertion of a mesh of fibrin in the area of brain injury, as support for intralesional administration of CM, in an experimental model of traumatic brain injury, does not seem to be a useful technique to optimize the functional results obtained with this type of therapy cell. <br/> |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lesión cerebral traumática |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
terapia celular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
gel de fibrina |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
traumatic brain injury |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell therapy |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
fibrin glue |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2009, v. 20, 4, p.243-248 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v20n4/pdf/02_06.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v20n4/pdf/02_06.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
