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04030nas a22003137a 4500 |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210406171114.0 |
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171219t2009 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Estudio de citoquinas y proteínas de choque térmico en pacientes polifracturados = |
| Remainder of title |
Study of cytokines and heat shock proteins in multiple fracture patients / |
| Statement of responsibility, etc. |
Ortiz Espada A, Chana Rodríguez F, Tisner Madrid M L, Vaquero Martín J, Guisasola Zulueta M C |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p. 209-210 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Valorar la repercusión y comportamiento de los niveles séricos de factores proinflamatorios con respecto a la aparición de complicaciones médico–quirúrgicas en pacientes politraumatizados.<br/>Material y métodos: se incluyeron 18 pacientes politraumatizados, 10 hombres y 8 mujeres, con 2 o más fracturas óseas y un ISS>16, con edad media de 42 años y cuyo mecanismo lesional más frecuente fue el accidente de tráfico (44%). El valor medio del ISS fue de 26,83 y de 33,72 para el NISS.<br/>Se recogieron datos demográficos, lesiones ocasionadas, intervenciones quirúrgicas realizadas, datos de evolución, complicaciones y secuelas. Se analizó en sangre, leucocitos, fibrinógeno, proteína C reactiva, TNFα, interleucina 1β, interleucina 6, proteína de choque térmico HSP70i y anticuerpos antiHSP70i.<br/>Resultados: Los valores de TNFα, tienen una curva ascendente, con un aumento de la pendiente a partir de las 48 horas del traumatismo. La IL-1‚ mostró el pico máximo en la primera medición inmediatamente después del traumatismo, para disminuir de manera progresiva. La IL-6 presentó cifras por encima de 500 pg/ml. Los niveles séricos elevados de HSP70i máximos en el momento inicial para disminuir en las siguientes 48 horas.<br/>Conclusiones: Las curvas de reacción de factores proinflamatorios establecidas servirán de base para futuros estudios que los afiancen como biomarcadores de politraumatismo. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: To evaluate the repercussion and behavior of the serum levels of proinflammatory factors in relation to the appearance of clinical-surgical complications in polytraumatized patients.<br/>Material and methods: The study comprised 18 polytraumatized patients, 10 males and 8 females, with two or more bone fractures and an injury severity score (ISS) >16, and with a mean age of 42 years, in which traffic accidents were the main cause of injury (44%). The mean ISS was 26.83, with a new injury severity score (NISS) of 33.72. Demographic data were collected, together with information on the injuries produced, the surgical interventions, outcome, complications and sequelae. Blood tests were performed to record leukocyte count, fibrinogen, C-reactive protein, TNF·, interleukin 1‚, interleukin 6, heat shock protein HSP70i and antiHSP70i antibodies.<br/>Results: The TNF· values showed an ascending tendency, with an increase in slope starting 48 hours after trauma. IL-1 in turn showed a maximum value on occasion of the first measurement immediately after injury, followed by a gradual decrease. IL-6 showed values above 500 pg/ml. Peak serum HSP70i elevation were recorded at first determination, followed by a decrease over the following 48 hours.<br/>Conclusions: The established proinflammatory factor response curves will serve as a basis for future studies to consolidate them as biomarkers applicable to polytraumatized patients.<br/> |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
politraumatismo |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
control de daños |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
citoquinas |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
proteínas de choque térmico |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
polytraumatism |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
damage control |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cytokines |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
heat shock proteins |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2009, v. 20, 4, p.201-210 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v20n4/pdf/02_01.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v20n4/pdf/02_01.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
