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03854nas a22003257a 4500 |
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20210414153935.0 |
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| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Inflamación sinovial en un modelo experimental de síndrome metabólico en conejo = |
| Remainder of title |
Synovial inflammation in an experimental model of metabolic syndrome in the rabbit / |
| Statement of responsibility, etc. |
Martínez-Calatrava MJ, Largo R, Prieto-Potín I, Herrero-Beaumont G. |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.26 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Analizar el efecto del síndrome metabólico (SM) sobre la inflamación sinovial en un modelo experimental en conejo.<br/>Material y métodos: Se probaron tres intervenciones dietéticas diferentes para inducir un modelo experimental de SM, en 21 conejos New Zealand hembra, de 8 meses de edad: 1) alimentación con dieta enriquecida con 1% de colesterol y 3% de aceite de cacahuete y agua ad libitum; 2) alimentación con dieta normal y agua con 30% de fructosa ad libitum; 3) alimentación con dieta enriquecida con 1% de colesterol y 3% de aceite de cacahuete y agua con 30% de fructosa ad limitum. Los animales se dejaron evolucionar durante 12 semanas y se hizo un seguimiento semanal de peso, glucosa basal, colesterol HDL, triglicéridos. Tras el sacrificio, se tomaron muestras de membrana sinovial para cuantificar el infiltrado macrofágico sinovial mediante inmunohistoquímica.<br/>Resultados: La única intervención dietética con la que conseguimos inducir alteraciones asociadas al SM en los conejos fue alimentándolos con una dieta hiperlipémica. Estos animales, además de presentar hiperglucemia y dislipemia, tenían un infiltrado macrofágico sinovial mayor que el del grupo control.<br/>Conclusión: La alimentación con dieta hiperlipémica induce alteraciones típicas del SM en el conejo, acompañadas de un aumento del infiltrado macrofágico sinovial, lo que sugiere que el macrófago podría desempeñar un papel importante en el inicio y/o la progresión de la artrosis descrita que se asocia con el SM. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objetive: To analyze the effect of metabolic syndrome (MS) upon synovial inflammation in an experimental model in the rabbit.<br/>Material and methodology: Three different diets were used to induce an experimental model of MS in 21 female New Zealand rabbits (aged 8 months): 1) diet enriched with 1% cholesterol and 3% peanut oil, with water, ad libitum; 2) normal diet, with water, and 30% fructose, ad libitum; 3) diet enriched with 1% cholesterol and 3% peanut oil, with water, and 30% fructose, ad libitum. The animals were followed-up on for 12 weeks, with weekly monitoring of body weight, basal glucose, HDL-cholesterol and triglycerides. Following sacrifice, synovial membrane samples were collected to quantify the synovial macrophage infiltrate using immunohistochemical techniques.<br/>Results: The only diet to induce alterations associated with MS in the rabbits was the hyperlipidemic diet.<br/>These animals, in addition to presenting hyperglycemia and dyslipidemia, showed greater synovial macrophage infiltration than the control group.<br/>Conclusion: A hyperlipidemic diet induces alterations typical of MS in the rabbit, accompanied by an increase in synovial macrophage infiltration. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
síndrome metabólico |
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modelo animal |
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| Uncontrolled term |
dieta |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
membrana sinovial |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
macrófago |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
metabolic syndrome |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
diet |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
synovial membrane |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
macrophage |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2011, v. 22, 1, p. 22-26 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v22n1/pdf/02_03.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v22n1/pdf/02_03.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
