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03847nas a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210414161425.0 |
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171219t2011 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 03 - TITLE STATEMENT |
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| Title |
El trasplante de astrocitos encapsulados mejoran el déficit motor en la habilidad manual producido por la lesión de la corteza frontal en ratas adultas = |
| Remainder of title |
Transplant of encapsulated astrocyte ameliorate lesion-induced motor deficits in adults rats with frontal cortex injury / |
| Statement of responsibility, etc. |
Heredia M, de la Fuente A, Criado JM, Jiménez-Díaz L, Yajeya J, Riolobos AS |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.287-288 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Investigar la capacidad de trasplantes de astrocitos encapsulados en esferas de alginato de recuperar el déficit en la habilidad manual producida por la lesión de la corteza frontal, en ratas adultas.<br/>Material y metodología: Se utilizaron ratas Wistar, y se emplearon pruebas conductuales, cultivos celulares, técnica de encapsulación de células y trasplantes. Los animales se condicionaron en un test de habilidad motora fina y se determinó su mano preferente. Se lesionó la corteza frontal contralateral a la mano preferente y se evaluó la efectividad de la lesión mediante el test de conducta. En un grupo de animales lesionados se trasplantó astrocitos encapsulados en esferas de alginato en la cavidad producida por la lesión; en un segundo grupo, se trasplantó tejido cortical fetal; y en un tercer grupo, se implantó esferas de alginato sin células.<br/>Resultados: A los tres meses post-trasplante, tanto los animales con trasplantes de astrocitos encapsulados como con trasplantes de tejido cortical mejoraron el déficit motor inducido por la lesión. Los animales con trasplantes de esferas de alginato vacías no experimentaron mejoría.<br/>Conclusión: Los trasplantes de astrocitos encapsulados mejoran, a largo plazo, el deficit motor. El alginato indujo efectos secundarios en el huésped. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objetive: To investigate whether transplants of encapsulated astrocytes in alginate spheres were able to recover the deficit in motor skills produced by frontal cortex lesion, in adult rats.<br/>Material and method: Male Wistar rats were used. Behavioral test, tissue culture, astrocyte transplants and immunocytochemical and histological techniques were applied. Animals were conditioned in a paw reaching for food task and the preferred paw determine. Lesion was produced in the frontal cortex contralateral to the preferred paw and the effectiveness of the lesion tested. In one group of lesion animals, encapsulated astrocytes in alginate spheres were implanted in the lesion cavity; in a second group, fetal cortical tissue was used as donor material; while in a third group empty alginate spheres were implanted.<br/>Results: Three months after grafting, the rats with encapsulated astrocyte or with fetal cortical tissue transplants ameliorated the lesion-induced motor deficit.The rats with implant of empty alginate spheres showed no improvement.<br/>Conclusion: Transplants of encapsulated astrocytes in alginate spheres induce a long- term improvement of motor lesion deficits. The alginate induced long-term side effects on the host |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
corteza motora |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
trasplantes de astrocitos |
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| Uncontrolled term |
alginato |
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| Uncontrolled term |
encapsulación |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
rata adulta |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
motor cortex |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
astrocyte transplants |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
alginate |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
encapsulation |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
adult rat |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2011, v. 22, 4, p. 281-288 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v22n4/pdf/02_09.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v22n4/pdf/02_09.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
