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03603nas a22003137a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210414161843.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
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171219t2012 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Tratamiento comparado de las lesiones del manguito rotador mediante el uso de células madre mesenquimales en combinación con membranas de colágeno tipo I = |
| Remainder of title |
Rotator cuff injury comparative treatment between isolated mesenchymal stem cells or combined with collagen I membranes / |
| Statement of responsibility, etc. |
Tornero-Esteban P, Hoyas JA, Villafuertes E, Rodríiguez-Bobada C, Guinea-Tortuero GV, Lópiz Y, FernándezGutiérrez B, Marco F |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.75 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Estudiar, en rata, la rotura completa del tendón del m. supraespinoso (SE) y su reparación mediante una membrana de colágeno tipo I con células mesenquimales pluripotenciales (MSCs).<br/>Material y método: Seccionamos unilateralmente el tendón SE, en ratas Sprague-Dawley de nueve meses de edad. Un mes después de la intervención, se realizó una segunda cirugía para reparar el tendón según tres grupos de tratamiento: cirugía convencional usando una sutura (n=30); con membrana de colágeno tipo I sin células (n=30) y con membrana de colágeno tipo I con 1x106 MSCs alogénicas (n=30; grupo MSC-Membrana). La reparación se evaluó al mes (n=30), a los dos2 meses (n=30) y a los nueve meses (n=30) mediante criterios biomecánicos e histológicos.<br/>Resultados: Las matrices de colágeno con MSC en los defectos creados mejoraron la resistencia y la rigidez del tendón SE a los tres meses comparado con las otras dos cirugías reparadoras. Ningún tratamiento logró un patrón histológicamente organizado.<br/>Conclusión: El tratamiento con MSC es seguro en los desgarros del manguito rotador |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: To study, in a rat model, the supraspinatus tendon (SE) rupture with isolated MSCs or combined with collagen membranes<br/>Material and method: A chronic rotator cuff tear injury model was developed by unilaterally detaching the SE tendon of aged Sprague-Dawley rats (9 months). One month post-injury, a second surgery was then performed to repair the tears by: 1. single suture (n=30), 2. suture and type I collagen membranes (n=30) and 3. suture and type I collagen membranes with 1x106 allogeneic MSCs; (n=30). Lesion restoration was evaluated at one month (n=30), two months (n=30) and three months (n=30) post-injury by biomechanical, histological and inmunohistological criterias.<br/>Results: All experimental conditions were well tolerated and no adverse effects were observed. Implantation of collagen type I membrane with MSCs into surgically created tendon defects improved strength and stiffness of SE tendon three months after treatment compared with the other two repair surgeries. No treatment achieved a histological organized pattern.<br/>Conclusion: The therapeutic use of allogenic MSCs in collagen type I membrane in the rotator cuff tears seems to be the most promising treatment in our experimental model. |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
manguito rotador |
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| Uncontrolled term |
hombro |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MSC |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
membrana colágeno |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
shoulder |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
rotator cuff |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
MSC |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
collagen scaffold |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2012, v. 23, Supl. 1, p. 70-75 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v23s1/docs/Articulo9.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v23s1/docs/Articulo9.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
