MARC details
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03919nas a22002897a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20210414165441.0 |
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171219t2012 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Influencia del grado de lesión neurológica sobre la eficacia de la terapia celular en un modelo de traumatismo craneoencefálico grave = |
| Remainder of title |
Influence of the level of neurological deficit on the efficacy of cell therapy in a model of severe traumatic brain injury / |
| Statement of responsibility, etc. |
Bonilla C, Zurita M, Otero L, Aguayo C, Rico MA, Vaquero J |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.104-105 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Determinar si el nivel de déficit neurológico influye en la eficacia de la terapia celular con células madre mesenquimales (CMM) de la médula ósea en un modelo experimental crónico de lesión cerebral traumática.<br/>Material y métodos: Se sometió a ratas Wistar adultas a un modelo de lesión cerebral traumática. Dos meses después, se clasificaron en función de su nivel de déficit neurológico mediante dos tests funcionales: Escala de valoración sensitivo-motora y Tiempo de permanencia en la zona interior (Video-Tracking-Box test, VTB test). Se inyectó suero salino solo o CMM en suero salino en el tejido cerebral dañado de los animales que obtuvieron la clasificación neurológica de lesión moderada o grave según el nivel permanente de su déficit funcional. Todos los animales se evaluaron durante los dos meses siguientes para determinar la posible eficacia de la administración de las CMM.<br/>Al finalizar el estudio, los animales se eutanasiaron y se estudiaron sus cerebros.<br/>Resultados: Se constata una recuperación funcional significativa en los animales con lesión moderada que recibieron las CMM, pero no en los animales con lesión grave cuando se compara con los controles.<br/>Conclusiones: Las conclusiones obtenidas sugieren que la gravedad de la lesión neurológica puede influir en la potencial eficacia de la terapia celular cuando es aplicada en una lesión cerebral traumática crónica. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: To study if the level of neurological deficit influences the efficacy of cell therapy with bone marrow stromal cells (BMSC), in an experimental model of chronic traumatic brain injury (TBI).<br/>Material and methods: Adult Wistar rats were subjected to a model of traumatic brain injury. Two months later they were classified according to their level of neurological deficit. For that, two functional tests: Scale of sensory-motor assessment and time spent in the inner zone in the Video-Tracking-Box test, were used. Saline alone or BMSC in saline was injected into the damaged brain tissue of animals suffering a permanent level of functional deficit classified as moderate or severe. All experimental groups were evaluated during the next two months to determine the potential effectiveness of the intracerebral administration of BMSC. At the end of the study animals were euthanized and their brains were studied.<br/>Results: The results show a significant functional recovery in animals with moderate injury who received BMSC, but there was no significant recovery in animals with severe traumatic brain injury when compared with controls.<br/>Conclusion: The severity of neurologic injury may influence the potential efficacy of cell therapy applied to chronic TBI |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lesión traumática cerebral |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
terapia celular |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre mesenquimales de la médula ósea |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
traumatic brain injury |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cell therapy |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
bone marrow stromal cells |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2012, v. 23, n. 2, p. 97-105 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v23n2/docs/Articulo5.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v23n2/docs/Articulo5.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
