MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04263nas a22003137a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20210420161233.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
|---|
| fixed length control field |
m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
171219t2012 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Valoración del daño cerebral tras la administración de surfactante = |
| Remainder of title |
Brain damage assesment after surfactant administration / |
| Statement of responsibility, etc. |
Murgia X, Rey Santano C, Ruiz del Yerro E, Mielgo V, Andrés L, Valls i Soler A |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliografía: p.261-262 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Objetivo: La terapia de reemplazo de surfactante se asocia frecuentemente a fluctuaciones del flujo sanguíneo cerebral (FSC). Presentamos la administración de surfactante nebulizado para evitar las fluctuaciones del FSC.<br/>Métodos: El estudio se llevó a cabo en muestras cerebrales (congeladas y fijadas) de corderos prematuros que recibieron surfactante instilado (SFinstil, administración clásica) o surfactante nebulizado (SFneb). Se analizaron el FSC regional, la actividad de las enzimas antioxidantes, el Factor de Necrosis Tumoral (TNFα) y el número de células apoptóticas (TUNEL). También se realizó una valoración semi-cuantitativa del daño cerebral por un anátomo-patólogo. Se analizaron zonas corticales (corteza frontal y occipital), zonas internas (tálamo, estriado e hipocampo), el cerebelo y el bulbo cefalorraquídeo.<br/>Resultados: La administración de surfactante nebulizado produjo una respuesta hemodinámica cerebral diferente<br/>a la instilación intratraqueal, especialmente en las zonas internas donde a los cinco minutos el FSC registrado resultó ser significativamente superior en el grupo SFinstil. No se registraron diferencias significativas en la actividad de las enzimas antioxidantes. El porcentaje de células positivas para TNFα y el número de células TUNEL positivas en las zonas internas fue significativamente superior en el grupo SFinstil (p<0.05). La valoración histológica determinó un mayor grado de necrosis neuronal (p<0.05) en el tálamo en el grupo SFinstil.<br/>Conclusión: La administración de surfactante en forma de aerosol debería tenerse en cuenta como una alternativa<br/>menos agresiva a la instilación intratraqueal. |
| 520 8# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Objective: Surfactant replacement therapy has been associated with cerebral blood flow (CBF) fluctuations. We propose the administration of aerosolized surfactant to prevent those fluctuations.<br/>Methods: Brain samples (frozen and paraffin-fixed) of preterm lambs received instilled surfactant (SFinstil, common<br/>administration) or aerosolized surfactant (SFneb). Regional CBF, the activity of antioxidant enzymes, the number of TNFα positive cells and the number of apoptotic cells (TUNEL) were determined. In addition, a semi-quantitative histological evaluation was performed by an expert pathologist. Cortical zones (frontal and occipital), inner zones (thalamus, striatum and hippocampus), cerebellum and the brain stem were analyzed.<br/>Results: Surfactant delivered as an aerosol produced a different cerebral hemodynamic response than surfactant instillation, especially towards the inner zones, where already five minutes after the start of the therapy the regional CBF<br/>was significantly higher in the SFinstil group. There were no differences between groups in the activity of antioxidant<br/>enzymes. The percentage of TNFα positive cells and the number of TUNEL positive cells in the inner zones was significantly higher in the SFinstil group. The histological score also showed a significantly higher necrosis in the SFinstil group compared to the SFneb group.<br/>Conclusion: Surfactant delivered as an aerosol should be considered as a less harmful method of surfactant administration. |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
prematuridad |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
surfactante |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
nebulización |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
flujo cerebral |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
prematurity |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
surfactant |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
nebulization |
| 653 14 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
cerebral fluctuations |
| 773 ## - HOST ITEM ENTRY |
|---|
| Related parts |
-- 2012, v. 23, n. 4, p. 253-262 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v23n4/docs/Articulo9.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v23n4/docs/Articulo9.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
