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03771nas a22003377a 4500 |
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OSt |
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20210420162139.0 |
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171219t2013 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Estudio experimental sobre los efectos de la quercetina en la disfunción orgánica y cognitiva originada por radiación ionizante = |
| Remainder of title |
Experimental study about the effects of quercetin on the organic and cognitive dysfunction induced by ionizing radiation / |
| Statement of responsibility, etc. |
Barrio JP, Marina R, Costilla SM, Rodríguez JR, Fernández CL, Ferreras MC, González P |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.31-32 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Comprobar el efecto de la incorporación de quercetina por vía oral sobre las alteraciones comportamentales, bioquímicas e histológicas de una dosis subletal de rayos X en la rata.<br/>Material y método: Se irradiaron a cuerpo entero con 6 Gy de rayos X ratas Wistar macho suplementadas o no<br/>con 50 mg/kg de quercetina. Se obtuvieron imágenes por RM a los dos, siete, 15 y 30 días tras la irradiación, y se<br/>observó el comportamiento exploratorio mediante open field antes y después de la irradiación. Los animales se<br/>sacrificaron a los siete y 30 días, obteniéndose muestras de sangre, cerebro, médula espinal y médula ósea.<br/>Resultados: Se observó un fuerte descenso en el recuento eritrocitario, leucocitario y plaquetario a los siete<br/>días, recuperándose a los 30 días los recuentos leucocitario y plaquetario, sin efecto de la quercetina. La RM<br/>mostraba focos de microsangrado consistentes con los hallazgos histológicos de infiltración celular por alteraciones neurovasculares, más evidentes en animales no suplementados. La quercetina atenuó estas alteraciones<br/>y revertió la disminución de la actividad exploratoria ocasionada por la irradiación.<br/>Conclusiones: El uso preventivo de quercetina podría mejorar los síntomas comportamentales y disminuir el<br/>daño tisular a corto plazo tras sesiones de radioterapia. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: To assess the effect of oral quercetin supplementation on the behavioral, biochemical, and histological alterations by a sublethal X-ray dose in rats.<br/>Materials and method: Male Wistar rats, supplemented with 50 mg/kg quercetin or solvent, were whole-body<br/>irradiated with 6 Gy X-rays. MRI was obtained at 2, 7, 15, and 30 days post-irradiation. Open field exploratory behavior was observed before and after irradiation. Rats were sacrificed at 7 and 30 days post-irradiation, and blood, brain, spinal cord, and bone marrow samples were obtained.<br/>Results: Red cell, white cell, and platelet counts strongly decreased at 7 days post-irradiation. White cell and<br/>platelet counts recovered at 30 days post-irradiation, with no effect by quercetin. MRI shows focal microbleeds consistent with the histological findings of cell infiltration by neurovascular alterations, more evident in<br/>non-supplemented rats. Quercetin improved these changes and reverted the decrease in exploratory activity<br/>due to Xirradiation.<br/>Conclusions: Preventive use of quercetin could improve early behavioral symptoms and decrease tissue damage appearing shortly after radiotherapy |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
comportamiento |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
quercetina |
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| Uncontrolled term |
radiación ionizante |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
rata |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
rayos X |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
behavior |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
quercetin |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ionizing radiation |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
rat |
| 653 14 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
X rays |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2013, v. 24, n. 1, p. 24-32 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v24n1/docs/Articulo4.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v24n1/docs/Articulo4.pdf</a> |
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Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
