MARC details
| 000 -LEADER |
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| fixed length control field |
03029nas a22002897a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20210420163602.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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m|||||r|||| 00| 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
171219t2013 sp ||||| |||| 00| 0 spa | |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1888-6116 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
Salus Infirmorum |
| 245 00 - TITLE STATEMENT |
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| Title |
Discapacidad grave tras daño cerebral traumático: posibilidades terapéuticas de la administración subaracnoidea de células estromales = |
| Remainder of title |
Severe disability after traumatic brain injury: therapeutic posibilities of subarachnoid administration of stromal cells / |
| Statement of responsibility, etc. |
Bonilla C, Zurita M, Otero L, Aguayo C, Rodríguez A, Rico MA |
| 500 ## - GENERAL NOTE |
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| General note |
Este artículo se encuentra disponible en su edición impresa. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliografía: p.237-238 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Objetivo: Estudiar el efecto terapéutico de la administración de células madre mesenquimales (CMM) para tratar secuelas neurológicas crónicas producidas tras una lesión cerebral. Material y método: En 20 ratas Wistar adultas y dos meses después de una lesión cerebral traumática, se realizó la administración subaracnoidea de CMM o suero. Se valoró la respuesta funcional de los animales y se hizo un análisis histológico del tejido cerebral. Resultados: No se obtuvieron mejoras significativas en la respuesta funcional de animales con CMM. Se localizaron CMM dentro del tejido cerebral, obteniéndose diferencias estadísticamente significativas en el tamaño de la lesión pero no en la expresión de marcadores neurales. Conclusión: El tratamiento subaracnoideo con CMM no tiene efecto en la respuesta neurológica de animales lesionados, aunque las células migraron y se integraron en el tejido cerebral, afectando a la morfología del mismo. |
| 520 8# - SUMMARY, ETC. |
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| Summary, etc. |
Objective: To study the therapeutic effect of administration of mesenchymal stem cells (MSCs) to treat chronic neurological sequelae produced after traumatic brain injury (TBI). Material and method: In 20 adult Wistar rats and two months after TBI, subarachnoid administration of CMM or saline were performed. Functional response of the animals was assessed and a histological analysis of brain tissue was conducted. Results: There was no significant improvement in the functional response in animals with MSCs. MSCs were located within the brain tissue obtained statistically significant difference in lesion size but not in the expression of neural markers. Conclusion: Subarachnoid treatment with MSCs has no effect on neurological response of injured animals, although the cells migrated and integrated into the brain tissue affecting their morphology. |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
trasplante subaracnoideo |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
lesión traumática cerebral |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
células madre mesenquimales |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
subarachnoid transplant |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
traumatic brain injury |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
mesenchymal stem cells |
| 773 ## - HOST ITEM ENTRY |
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| Related parts |
-- 2013, v. 24, n. 4, p. 230-238 |
| Title |
Trauma |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://www.mapfre.com/fundacion/html/revistas/trauma/v24n4/docs/Articulo6.pdf">http://www.mapfre.com/fundacion/html/revistas/trauma/v24n4/docs/Articulo6.pdf</a> |
| Link text |
Acceso al documento |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Universal Decimal Classification |
| Koha item type |
Artículo de revista |
